Coreg, Coreg CR (carvedilol) dosing, indications, interactions, adverse effects, and more (2023)

  • abiraterone

    abiraterone increases levels of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Avoid coadministration of abiraterone with substrates of CYP2D6. If alternative therapy cannot be used, exercise caution and consider a dose reduction of the CYP2D6 substrate.

  • acebutolol

    acebutolol and carvedilol both increase serum potassium. Use Caution/Monitor.

  • aceclofenac

    carvedilol and aceclofenac both increase serum potassium. Use Caution/Monitor.aceclofenac decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • acemetacin

    carvedilol and acemetacin both increase serum potassium. Use Caution/Monitor.acemetacin decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • albuterol

    carvedilol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.

  • aldesleukin

    aldesleukin increases effects of carvedilol by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • alfuzosin

    alfuzosin and carvedilol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.

  • aluminum hydroxide

    aluminum hydroxide decreases levels of carvedilol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.

  • amifostine

    amifostine, carvedilol.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration with blood pressure lowering agents may increase the risk and severity of hypotension associated with amifostine. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine.

  • amiloride

    carvedilol and amiloride both increase serum potassium. Modify Therapy/Monitor Closely.

  • amiodarone

    amiodarone will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.amiodarone will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Monitor for signs of bradycardia or heart block when amiodarone and a beta adrenergic blocker are coadministered. Amiodarone should be used with caution in patients receiving a beta adrenergic blocker, particularly if there is suspicion of underlying dysfunction of the sinus node, such as bradycardia or sick sinus syndrome, or if there is partial AV block.amiodarone, carvedilol. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of cardiotoxicity with bradycardia.

  • amlodipine

    carvedilol and amlodipine both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.

  • amobarbital

    amobarbital will decrease the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.amobarbital decreases levels of carvedilol by increasing metabolism. Use Caution/Monitor. Consider a higher beta-blocker dose during coadministration of amobarbital. Atenolol, sotalol, nadolol less likely to be affected than other beta blockers.

  • apalutamide

    apalutamide will decrease the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Coadministration of apalutamide, a weak CYP2C9 inducer, with drugs that are CYP2C9 substrates can result in lower exposure to these medications. Evaluate for loss of therapeutic effect if medication must be coadministered.apalutamide will decrease the level or effect of carvedilol by increasing elimination. Use Caution/Monitor. Apalutamide induces UGT and may decrease systemic exposure of drugs that are UGT substrates.

  • arformoterol

    carvedilol increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of arformoterol by pharmacodynamic antagonism. Use Caution/Monitor.

  • asenapine

    asenapine will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.asenapine and carvedilol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.

  • aspirin

    carvedilol and aspirin both increase serum potassium. Use Caution/Monitor.aspirin decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • aspirin rectal

    carvedilol and aspirin rectal both increase serum potassium. Use Caution/Monitor.aspirin rectal decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • aspirin/citric acid/sodium bicarbonate

    aspirin/citric acid/sodium bicarbonate decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.carvedilol and aspirin/citric acid/sodium bicarbonate both increase serum potassium. Use Caution/Monitor.

  • atazanavir

    atazanavir increases effects of carvedilol by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of hypotension, bradycardia, AV block, and prolonged PR interval. Consider lowering beta blocker dose.

  • atenolol

    atenolol and carvedilol both increase serum potassium. Use Caution/Monitor.

  • avanafil

    avanafil increases effects of carvedilol by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • bendroflumethiazide

    carvedilol increases and bendroflumethiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • berotralstat

    carvedilol increases levels of berotralstat by P-glycoprotein (MDR1) efflux transporter. Modify Therapy/Monitor Closely. Reduced berotralstat dose to 110 mg/day when coadministered with P-gp inhibitors.berotralstat will increase the level or effect of carvedilol by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Monitor or titrate P-gp substrate dose if coadministered.

  • betaxolol

    betaxolol and carvedilol both increase serum potassium. Use Caution/Monitor.

  • betrixaban

    carvedilol increases levels of betrixaban by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Decrease betrixaban dose to 80 mg PO once, then 40 mg PO qDay if coadministered with a P-gp inhibitor.

  • bismuth subsalicylate

    bismuth subsalicylate, carvedilol. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Blockage of renal prostaglandin synthesis; may cause severe hypertension.

  • bisoprolol

    bisoprolol and carvedilol both increase serum potassium. Use Caution/Monitor.

  • bosentan

    bosentan will decrease the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • bosutinib

    bosutinib increases levels of carvedilol by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • bretylium

    carvedilol, bretylium.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Each drug may cause hypotension.

  • bumetanide

    carvedilol increases and bumetanide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • bupropion

    bupropion will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • butabarbital

    butabarbital will decrease the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.butabarbital decreases levels of carvedilol by increasing metabolism. Use Caution/Monitor. Consider a higher beta-blocker dose during coadministration of butabarbital. Atenolol, sotalol, nadolol less likely to be affected than other beta blockers.

  • butalbital

    butalbital will decrease the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.butalbital decreases levels of carvedilol by increasing metabolism. Use Caution/Monitor. Consider a higher beta-blocker dose during coadministration of butalbital. Atenolol, sotalol, nadolol less likely to be affected than other beta blockers.

  • calcium acetate

    calcium acetate decreases effects of carvedilol by unspecified interaction mechanism. Use Caution/Monitor.

  • calcium carbonate

    calcium carbonate decreases effects of carvedilol by unspecified interaction mechanism. Use Caution/Monitor.calcium carbonate decreases levels of carvedilol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.

  • calcium chloride

    calcium chloride decreases effects of carvedilol by unspecified interaction mechanism. Use Caution/Monitor.

  • calcium citrate

    calcium citrate decreases effects of carvedilol by unspecified interaction mechanism. Use Caution/Monitor.

  • calcium gluconate

    calcium gluconate decreases effects of carvedilol by unspecified interaction mechanism. Use Caution/Monitor.

  • candesartan

    candesartan and carvedilol both increase serum potassium. Use Caution/Monitor.carvedilol, candesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • cannabidiol

    cannabidiol will increase the level or effect of carvedilol by decreasing metabolism. Modify Therapy/Monitor Closely. Cannabidiol may potentially inhibit CYP2C9 activity. Consider reducing the dose when concomitantly using CYP2C9 substrates.

  • carbamazepine

    carbamazepine will decrease the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • carbenoxolone

    carvedilol increases and carbenoxolone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • carbidopa

    carbidopa increases effects of carvedilol by pharmacodynamic synergism. Use Caution/Monitor. Therapy with carbidopa, given with or without levodopa or carbidopa-levodopa combination products, is started, dosage adjustment of the antihypertensive drug may be required.

  • celecoxib

    celecoxib will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.carvedilol and celecoxib both increase serum potassium. Use Caution/Monitor.celecoxib decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • celiprolol

    carvedilol and celiprolol both increase serum potassium. Use Caution/Monitor.

  • ceritinib

    carvedilol increases levels of ceritinib by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • chloroquine

    chloroquine will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

    (Video) Coreg CR For the Treatment of Heart Failure and High Blood Pressure in Adults - Overview

  • chlorothiazide

    carvedilol increases and chlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • chlorthalidone

    carvedilol increases and chlorthalidone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • choline magnesium trisalicylate

    carvedilol and choline magnesium trisalicylate both increase serum potassium. Use Caution/Monitor.choline magnesium trisalicylate decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • cimetidine

    cimetidine will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.cimetidine will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • citalopram

    citalopram increases levels of carvedilol by decreasing metabolism. Use Caution/Monitor.

  • clevidipine

    carvedilol and clevidipine both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.

  • clobazam

    clobazam will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly.

  • cobicistat

    cobicistat will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • crizotinib

    crizotinib increases levels of carvedilol by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • cyclopenthiazide

    carvedilol increases and cyclopenthiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dabigatran

    carvedilol will increase the level or effect of dabigatran by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Atrial fibrillation: Avoid coadministering dabigatran with P-gp inhibitors if CrCl <30 mL/min. DVT/PE treatment: Avoid coadministering dabigatran with P-gp inhibitors if CrCl <50 mL/min

  • darifenacin

    darifenacin will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • darunavir

    darunavir will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • desflurane

    desflurane, carvedilol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • desvenlafaxine

    desvenlafaxine will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses <100 mg

  • dichlorphenamide

    dichlorphenamide and carvedilol both decrease serum potassium. Use Caution/Monitor.

  • diclofenac

    carvedilol and diclofenac both increase serum potassium. Use Caution/Monitor.diclofenac decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • diflunisal

    carvedilol and diflunisal both increase serum potassium. Use Caution/Monitor.diflunisal decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • digoxin

    carvedilol and digoxin both increase serum potassium. Use Caution/Monitor.carvedilol increases levels of digoxin by enhancing GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.carvedilol increases levels of digoxin by decreasing renal clearance. Use Caution/Monitor.carvedilol increases effects of digoxin by pharmacodynamic synergism. Use Caution/Monitor. Enhanced bradycardia.

  • diltiazem

    carvedilol and diltiazem both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.

  • diphenhydramine

    diphenhydramine will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • dobutamine

    carvedilol increases and dobutamine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of dobutamine by pharmacodynamic antagonism. Use Caution/Monitor.

  • dopexamine

    carvedilol increases and dopexamine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of dopexamine by pharmacodynamic antagonism. Use Caution/Monitor.

  • doxazosin

    doxazosin and carvedilol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.

  • dronedarone

    dronedarone will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • drospirenone

    carvedilol and drospirenone both increase serum potassium. Modify Therapy/Monitor Closely.

  • duvelisib

    carvedilol will increase the level or effect of duvelisib by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • elagolix

    elagolix will increase the level or effect of carvedilol by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • eliglustat

    eliglustat increases levels of carvedilol by P-glycoprotein (MDR1) efflux transporter. Modify Therapy/Monitor Closely. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the P-gp substrate and titrate to clinical effect.eliglustat increases levels of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect.

  • elvitegravir/cobicistat/emtricitabine/tenofovir DF

    elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP2D6 inhibitor; caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events.elvitegravir/cobicistat/emtricitabine/tenofovir DF decreases levels of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Elvitegravir is a moderate CYP2C9 inducer.

  • ephedrine

    carvedilol increases and ephedrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of ephedrine by pharmacodynamic antagonism. Use Caution/Monitor.

  • epinephrine

    carvedilol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor.

  • epinephrine racemic

    carvedilol increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of epinephrine racemic by pharmacodynamic antagonism. Use Caution/Monitor.

  • eprosartan

    eprosartan and carvedilol both increase serum potassium. Use Caution/Monitor.carvedilol, eprosartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • esmolol

    carvedilol and esmolol both increase serum potassium. Use Caution/Monitor.

  • ethacrynic acid

    carvedilol increases and ethacrynic acid decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • ethanol

    ethanol increases levels of carvedilol by Other (see comment). Use Caution/Monitor. Comment: ETOH may affect the release rate of extended-release carvedilol (Coreg CR), resulting in higher peak plasma concentration. Separate by 2 hr. Immediate-release carvedilol (Coreg) not affected.

  • ether

    carvedilol, ether.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Both beta blockers and ether depress the myocardium; consider lowering beta blocker dose if ether used for anesthesia.

  • etodolac

    carvedilol and etodolac both increase serum potassium. Use Caution/Monitor.etodolac decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • etomidate

    etomidate, carvedilol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • etravirine

    etravirine will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • fedratinib

    fedratinib will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Adjust dose of drugs that are CYP2D6 substrates as necessary.

  • felbamate

    felbamate will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • felodipine

    carvedilol and felodipine both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.

  • fenbufen

    carvedilol and fenbufen both increase serum potassium. Use Caution/Monitor.

  • fenoprofen

    carvedilol and fenoprofen both increase serum potassium. Use Caution/Monitor.fenoprofen decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • fingolimod

    carvedilol increases effects of fingolimod by pharmacodynamic synergism. Use Caution/Monitor. Both medications decrease heart rate. Monitor patients on concomitant therapy, particularly in the first 6 hours after fingolimod is initiated or after a treatment interruption of at least two weeks, for bradycardia and atrioventricular block. To identify underlying risk factors of bradycardia and AV block, obtain a new or recent ECG in patients using beta-blockers prior to starting fingolimod.

  • fluconazole

    fluconazole will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • fluoxetine

    fluoxetine will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

    (Video) Carvedilol ( Coreg ): What is Carvedilol Used For, Dosage, Side Effects & Precautions?

  • flurbiprofen

    carvedilol and flurbiprofen both increase serum potassium. Use Caution/Monitor.flurbiprofen decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • fluvoxamine

    fluvoxamine will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • formoterol

    carvedilol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor.

  • fostamatinib

    fostamatinib will increase the level or effect of carvedilol by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Concomitant use of fostamatinib may increase concentrations of P-gp substrates. Monitor for toxicities of the P-gp substrate drug that may require dosage reduction when given concurrently with fostamatinib.

  • furosemide

    carvedilol increases and furosemide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • gentamicin

    carvedilol increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • glecaprevir/pibrentasvir

    carvedilol will increase the level or effect of glecaprevir/pibrentasvir by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.glecaprevir/pibrentasvir will increase the level or effect of carvedilol by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • glucagon

    glucagon decreases toxicity of carvedilol by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Coadministration of glucagon with beta-blockers may have transiently increased pulse and blood pressure.

  • glucagon intranasal

    glucagon intranasal decreases toxicity of carvedilol by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Coadministration of glucagon with beta-blockers may have transiently increased pulse and blood pressure.

  • haloperidol

    haloperidol will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • hydralazine

    hydralazine increases effects of carvedilol by pharmacodynamic synergism. Use Caution/Monitor. Additive hypotensive effects.carvedilol increases effects of hydralazine by pharmacodynamic synergism. Use Caution/Monitor. Additive hypotensive effects.

  • hydrochlorothiazide

    carvedilol increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • ibuprofen

    carvedilol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • ibuprofen IV

    ibuprofen IV decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.carvedilol and ibuprofen IV both increase serum potassium. Use Caution/Monitor.

  • imatinib

    imatinib will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.imatinib will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • indapamide

    carvedilol increases and indapamide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • indomethacin

    carvedilol and indomethacin both increase serum potassium. Use Caution/Monitor.indomethacin decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • insulin degludec

    carvedilol, insulin degludec. Other (see comment). Modify Therapy/Monitor Closely. Comment: Beta-blockers may either increase or decrease the blood glucose lowering effect of insulin; beta-blockers can prolong hypoglycemia (interference with glycogenolysis) or cause hyperglycemia (insulin secretion inhibited).

  • insulin degludec/insulin aspart

    carvedilol, insulin degludec/insulin aspart. Other (see comment). Modify Therapy/Monitor Closely. Comment: Beta-blockers may either increase or decrease the blood glucose lowering effect of insulin; beta-blockers can prolong hypoglycemia (interference with glycogenolysis) or cause hyperglycemia (insulin secretion inhibited).

  • insulin inhaled

    carvedilol, insulin inhaled. Other (see comment). Modify Therapy/Monitor Closely. Comment: Beta-blockers may either increase or decrease the blood glucose lowering effect of insulin; beta-blockers can prolong hypoglycemia (interference with glycogenolysis) or cause hyperglycemia (insulin secretion inhibited).

  • iodixanol

    carvedilol increases toxicity of iodixanol by unspecified interaction mechanism. Use Caution/Monitor. Use of beta-blockers lowers the threshold for and increases the severity of contrast reactions, and reduces the responsiveness of treatment of hypersensitivity reactions with epinephrine. .

  • irbesartan

    irbesartan and carvedilol both increase serum potassium. Use Caution/Monitor.carvedilol, irbesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • isoproterenol

    carvedilol increases and isoproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of isoproterenol by pharmacodynamic antagonism. Use Caution/Monitor.

  • isradipine

    carvedilol and isradipine both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.

  • istradefylline

    istradefylline will increase the level or effect of carvedilol by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Istradefylline 40 mg/day increased peak levels and AUC of P-gp substrates in clinical trials. Consider dose reduction of sensitive P-gp substrates.

  • ivabradine

    ivabradine, carvedilol.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Most patients receiving ivabradine will also be treated with a beta-blocker. The risk of bradycardia increases with coadministration of drugs that slow heart rate (eg, digoxin, amiodarone, beta-blockers). Monitor heart rate in patients taking ivabradine with other negative chronotropes.

  • ivacaftor

    ivacaftor increases levels of carvedilol by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Ivacaftor and its M1 metabolite has the potential to inhibit P-gp; may significantly increase systemic exposure to sensitive P-gp substrates with a narrow therapeutic index.

  • ketamine

    ketamine, carvedilol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • ketoconazole

    ketoconazole will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • ketoprofen

    carvedilol and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • ketorolac

    carvedilol and ketorolac both increase serum potassium. Use Caution/Monitor.ketorolac decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • ketorolac intranasal

    carvedilol and ketorolac intranasal both increase serum potassium. Use Caution/Monitor.ketorolac intranasal decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • labetalol

    carvedilol and labetalol both increase serum potassium. Use Caution/Monitor.

  • lasmiditan

    carvedilol increases effects of lasmiditan by pharmacodynamic synergism. Use Caution/Monitor. Lasmiditan has been associated with a lowering of heart rate (HR). In a drug interaction study, addition of a single 200-mg dose of lasmiditan to propranolol decreased HR by an additional 5 bpm compared to propranolol alone, for a mean maximum of 19 bpm.

  • leflunomide

    leflunomide will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • levalbuterol

    carvedilol increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of levalbuterol by pharmacodynamic antagonism. Use Caution/Monitor.

  • levodopa

    levodopa increases effects of carvedilol by pharmacodynamic synergism. Use Caution/Monitor. Consider decreasing dosage of antihypertensive agent.

  • levoketoconazole

    levoketoconazole will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • lomitapide

    lomitapide increases levels of carvedilol by P-glycoprotein (MDR1) efflux transporter. Modify Therapy/Monitor Closely. Consider reducing dose when used concomitantly with lomitapide.

  • lorcaserin

    lorcaserin will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • lornoxicam

    carvedilol and lornoxicam both increase serum potassium. Use Caution/Monitor.lornoxicam decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • losartan

    losartan and carvedilol both increase serum potassium. Use Caution/Monitor.carvedilol, losartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • lumacaftor/ivacaftor

    lumacaftor/ivacaftor, carvedilol. affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. In vitro studies suggest that lumacaftor may induce and ivacaftor may inhibit CYP2C9 substrates. .

  • lurasidone

    lurasidone increases effects of carvedilol by Other (see comment). Use Caution/Monitor. Comment: Potential for increased risk of hypotension with concurrent use. Monitor blood pressure and adjust dose of antihypertensive agent as needed.

  • maraviroc

    maraviroc will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • marijuana

    marijuana will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • meclofenamate

    meclofenamate decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.carvedilol and meclofenamate both increase serum potassium. Use Caution/Monitor.

  • mefenamic acid

    carvedilol and mefenamic acid both increase serum potassium. Use Caution/Monitor.mefenamic acid decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • mefloquine

    mefloquine increases levels of carvedilol by decreasing metabolism. Use Caution/Monitor. Risk of arrhythmia.

    (Video) How To Use Carvedilol? (Coreg) - Use, Dose, Side Effects - Doctor Explains

  • meloxicam

    carvedilol and meloxicam both increase serum potassium. Use Caution/Monitor.meloxicam decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • metaproterenol

    carvedilol increases and metaproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of metaproterenol by pharmacodynamic antagonism. Use Caution/Monitor.

  • methyclothiazide

    carvedilol increases and methyclothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

  • metolazone

    carvedilol increases and metolazone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • metoprolol

    carvedilol and metoprolol both increase serum potassium. Use Caution/Monitor.

  • metronidazole

    metronidazole will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • miconazole vaginal

    miconazole vaginal will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • mirabegron

    mirabegron will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • moxisylyte

    moxisylyte and carvedilol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.

  • nabumetone

    carvedilol and nabumetone both increase serum potassium. Use Caution/Monitor.nabumetone decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • nadolol

    carvedilol and nadolol both increase serum potassium. Use Caution/Monitor.

  • naldemedine

    carvedilol increases levels of naldemedine by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Monitor naldemedine for potential adverse effects if coadministered with P-gp inhibitors.

  • naproxen

    carvedilol and naproxen both increase serum potassium. Use Caution/Monitor.naproxen decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • nateglinide

    nateglinide will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • nebivolol

    carvedilol and nebivolol both increase serum potassium. Use Caution/Monitor.

  • nicardipine

    carvedilol and nicardipine both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.

  • nifedipine

    carvedilol and nifedipine both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.

  • nilotinib

    nilotinib will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.nilotinib will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • nintedanib

    carvedilol increases levels of nintedanib by P-glycoprotein (MDR1) efflux transporter. Modify Therapy/Monitor Closely. If nintedanib adverse effects occur, management may require interruption, dose reduction, or discontinuation of therapy.

  • nisoldipine

    carvedilol and nisoldipine both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.

  • nitisinone

    nitisinone will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Nitisinone inhibits CYP2C9. Caution if CYP2C9 substrate coadministered, particularly those with a narrow therapeutic index.

  • nitroglycerin rectal

    nitroglycerin rectal, carvedilol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Beta-blockers blunt the reflex tachycardia produced by nitroglycerin without preventing its hypotensive effects. If beta-blockers are used with nitroglycerin in patients with angina pectoris, additional hypotensive effects may occur.

  • norepinephrine

    carvedilol increases and norepinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of norepinephrine by pharmacodynamic antagonism. Use Caution/Monitor.

  • olmesartan

    olmesartan and carvedilol both increase serum potassium. Use Caution/Monitor.carvedilol, olmesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • olodaterol inhaled

    carvedilol, olodaterol inhaled.Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor. Beta-blockers and olodaterol may interfere with the effect of each other when administered concurrently. Beta-blockers may produce severe bronchospasm in COPD patients. Therefore, patients with COPD should not normally be treated with beta-blockers. However, under certain circumstances, e.g. as prophylaxis after myocardial infarction, there may be no acceptable alternatives to the use of beta-blockers in patients with COPD. In this setting, cardioselective beta-blockers could be considered, although they should be administered with caution.

  • oxaprozin

    carvedilol and oxaprozin both increase serum potassium. Use Caution/Monitor.oxaprozin decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • oxymetazoline topical

    oxymetazoline topical increases and carvedilol decreases sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • parecoxib

    parecoxib will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.carvedilol and parecoxib both increase serum potassium. Use Caution/Monitor.parecoxib decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • penbutolol

    carvedilol and penbutolol both increase serum potassium. Use Caution/Monitor.

  • pentobarbital

    pentobarbital will decrease the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.pentobarbital decreases levels of carvedilol by increasing metabolism. Use Caution/Monitor. Consider a higher beta-blocker dose during coadministration of pentobarbital. Atenolol, sotalol, nadolol less likely to be affected than other beta blockers.

  • perphenazine

    perphenazine will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • phenobarbital

    phenobarbital will decrease the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.phenobarbital decreases levels of carvedilol by increasing metabolism. Use Caution/Monitor. Consider a higher beta-blocker dose during coadministration of phenobarbital. Atenolol, sotalol, nadolol less likely to be affected than other beta blockers.

  • phenoxybenzamine

    phenoxybenzamine and carvedilol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.

  • phentolamine

    phentolamine and carvedilol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.

  • pindolol

    carvedilol and pindolol both increase serum potassium. Use Caution/Monitor.

  • pirbuterol

    carvedilol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.

  • piroxicam

    carvedilol and piroxicam both increase serum potassium. Use Caution/Monitor.piroxicam decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • ponatinib

    ponatinib increases levels of carvedilol by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • ponesimod

    ponesimod and carvedilol both increase pharmacodynamic synergism. Use Caution/Monitor. Beta-blockers may have additive effects on lowering HR. Consider resting HR before initiating ponesimod in patients on stable dose of beta-blocker. Refer to the ponesimod prescribing information for more dosing information.

  • potassium acid phosphate

    carvedilol and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.

  • potassium chloride

    carvedilol and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

  • potassium citrate

    carvedilol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

  • prazosin

    prazosin and carvedilol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.

  • primidone

    primidone will decrease the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.primidone decreases levels of carvedilol by increasing metabolism. Use Caution/Monitor. Consider a higher beta-blocker dose during coadministration of primidone. Atenolol, sotalol, nadolol less likely to be affected than other beta blockers.

  • propafenone

    propafenone will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • propofol

    propofol, carvedilol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • propranolol

    carvedilol and propranolol both increase serum potassium. Use Caution/Monitor.

  • quinacrine

    quinacrine will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • ranolazine

    ranolazine will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

    (Video) Carvedilol - Mechanism, precautions, side effects & uses

  • rifabutin

    rifabutin decreases levels of carvedilol by increasing metabolism. Use Caution/Monitor.

  • rifampin

    rifampin will decrease the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.rifampin decreases levels of carvedilol by increasing metabolism. Use Caution/Monitor.

  • rifapentine

    rifapentine will decrease the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.rifapentine decreases levels of carvedilol by increasing metabolism. Use Caution/Monitor.

  • rifaximin

    carvedilol increases levels of rifaximin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • ritonavir

    ritonavir will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • rolapitant

    rolapitant will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Rolapitant may increase plasma concentrations of CYP2D6 substrates for at least 28 days following rolapitant administration.

  • rucaparib

    rucaparib will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Modify Therapy/Monitor Closely. Adjust dosage of CYP2C9 substrates, if clinically indicated.

  • sacubitril/valsartan

    sacubitril/valsartan and carvedilol both increase serum potassium. Use Caution/Monitor.carvedilol, sacubitril/valsartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • salicylates (non-asa)

    carvedilol and salicylates (non-asa) both increase serum potassium. Use Caution/Monitor.salicylates (non-asa) decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • salmeterol

    carvedilol increases and salmeterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of salmeterol by pharmacodynamic antagonism. Use Caution/Monitor.

  • salsalate

    carvedilol and salsalate both increase serum potassium. Use Caution/Monitor.salsalate decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • saquinavir

    saquinavir, carvedilol.Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Use alternatives if available. Increased risk of PR prolongation and cardiac arrhythmias.

  • sarecycline

    sarecycline will increase the level or effect of carvedilol by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Monitor for toxicities of P-gp substrates that may require dosage reduction when coadministered with P-gp inhibitors.

  • secobarbital

    secobarbital will decrease the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.secobarbital decreases levels of carvedilol by increasing metabolism. Use Caution/Monitor. Consider a higher beta-blocker dose during coadministration of secobarbital. Atenolol, sotalol, nadolol less likely to be affected than other beta blockers.

  • sertraline

    sertraline will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • sevoflurane

    sevoflurane, carvedilol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • sildenafil

    carvedilol increases effects of sildenafil by additive vasodilation. Use Caution/Monitor. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy.

  • silodosin

    silodosin and carvedilol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.

  • siponimod

    siponimod, carvedilol.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Caution when siponimod is initiated in patients receiving beta-blocker treatment because of additive effects on lowering heart rate. Temporary interruption of beta-blocker may be needed before initiating siponimod. Beta-blocker treatment can be initiated in patients receiving stable doses of siponimod.

  • sodium bicarbonate

    sodium bicarbonate decreases levels of carvedilol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.

  • sodium citrate/citric acid

    sodium citrate/citric acid decreases levels of carvedilol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.

  • sotalol

    carvedilol and sotalol both increase serum potassium. Use Caution/Monitor.

  • spironolactone

    carvedilol and spironolactone both increase serum potassium. Modify Therapy/Monitor Closely.

  • stiripentol

    stiripentol will increase the level or effect of carvedilol by P-glycoprotein (MDR1) efflux transporter. Modify Therapy/Monitor Closely. Consider reducing the dose of P-glycoprotein (P-gp) substrates, if adverse reactions are experienced when administered concomitantly with stiripentol.

  • succinylcholine

    carvedilol and succinylcholine both increase serum potassium. Use Caution/Monitor.

  • sulfamethoxazole

    sulfamethoxazole will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • sulfasalazine

    carvedilol and sulfasalazine both increase serum potassium. Use Caution/Monitor.sulfasalazine decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • sulindac

    carvedilol and sulindac both increase serum potassium. Use Caution/Monitor.sulindac decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • tadalafil

    tadalafil increases effects of carvedilol by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • telmisartan

    telmisartan and carvedilol both increase serum potassium. Use Caution/Monitor.carvedilol, telmisartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • terazosin

    terazosin and carvedilol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.

  • terbinafine

    terbinafine will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Assess need to reduce dose of CYP2D6-metabolized drug.

  • terbutaline

    carvedilol increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of terbutaline by pharmacodynamic antagonism. Use Caution/Monitor.

  • theophylline

    carvedilol, theophylline. Other (see comment). Use Caution/Monitor. Comment: Beta blockers (esp. non selective) antagonize theophylline effects, while at the same time increasing theophylline levels and toxicity (mechanism: decreased theophylline metabolism). Smoking increases risk of interaction.

  • thioridazine

    thioridazine will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • ticlopidine

    ticlopidine will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • timolol

    carvedilol and timolol both increase serum potassium. Use Caution/Monitor.

  • tipranavir

    tipranavir will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • tolfenamic acid

    carvedilol and tolfenamic acid both increase serum potassium. Use Caution/Monitor.tolfenamic acid decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • tolmetin

    carvedilol and tolmetin both increase serum potassium. Use Caution/Monitor.tolmetin decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • tolvaptan

    carvedilol and tolvaptan both increase serum potassium. Use Caution/Monitor.

  • torsemide

    carvedilol increases and torsemide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • triamterene

    carvedilol and triamterene both increase serum potassium. Modify Therapy/Monitor Closely.

  • tucatinib

    tucatinib will increase the level or effect of carvedilol by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Consider reducing the dosage of P-gp substrates, where minimal concentration changes may lead to serious or life-threatening toxicities.

  • valproic acid

    valproic acid will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • valsartan

    valsartan and carvedilol both increase serum potassium. Use Caution/Monitor.carvedilol, valsartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • vemurafenib

    vemurafenib increases levels of carvedilol by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • venlafaxine

    venlafaxine will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • verapamil

    carvedilol and verapamil both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.

    (Video) Carvedilol - Coreg

  • voriconazole

    voriconazole will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • xipamide

    xipamide increases effects of carvedilol by pharmacodynamic synergism. Use Caution/Monitor.

  • zafirlukast

    zafirlukast will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • FAQs

    What is the indication of Coreg? ›

    COREG is indicated for the treatment of mild-to-severe chronic heart failure of ischemic or cardiomyopathic origin, usually in addition to diuretics, ACE inhibitors, and digitalis, to increase survival and, also, to reduce the risk of hospitalization [see DRUG INTERACTIONS , Clinical Studies].

    What is Coreg CR used for? ›

    Carvedilol is used to treat high blood pressure and heart failure. It is also used after a heart attack to improve the chance of survival if your heart is not pumping well. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.

    What are the side effects for Coreg? ›

    Dizziness, lightheadedness, drowsiness, diarrhea, impotence, or tiredness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

    Does Coreg affect blood pressure? ›

    Coreg (Carvedilol) is an alpha and beta blocker medication. It lowers blood pressure by relaxing blood vessels (by blocking alpha receptors) and slowing heart rate (by blocking beta receptors).

    Who should not use carvedilol? ›

    For carvedilol, contraindications include: Bronchial asthma: Carvedilol can cause life-threatening airway closure in these patients. Second- or third-degree AV block, sick sinus syndrome, or very slow heartbeat (bradycardia): All three are serious problems with the heart's ability to beat normally.

    What is a potential danger or side effect of carvedilol? ›

    If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure.

    What should I avoid while taking carvedilol? ›

    Alcohol (Ethanol) carvedilol

    Carvedilol and ethanol may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate.

    Does carvedilol affect sleep? ›

    Beta blockers are a large group of medications that are often used for high blood pressure and other heart conditions. Top examples are metoprolol succinate (Toprol XL), carvedilol (Coreg), and propranolol. However, they can cause side effects — including sleep disturbances like insomnia and nightmares.

    Does Coreg make you pee more? ›

    chest pain, dry cough, wheezing, chest tightness; heart problems--swelling, rapid weight gain, feeling short of breath; or. high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor.

    Does carvedilol lower blood pressure immediately? ›

    Carvedilol usually starts to work after about 1 hour. But it will take days or weeks to reach its full effect. You may not feel any different when you take carvedilol for high blood pressure, but this does not mean it's not working. It's important to keep taking your medicine.

    Does carvedilol protect your kidneys? ›

    Carvedilol decreases renal vascular resistance and prevents reductions in the glomerular filtration rate and renal blood flow in patients with hypertension with or without impaired kidney function.

    What is the difference between carvedilol and Coreg? ›

    Carvedilol is the generic drug name for the brand Coreg or Coreg CR (Extended-Release).

    At what blood pressure should you hold carvedilol? ›

    Teach patient and family how to check pulse and BP. Instruct them to check pulse daily and BP biweekly. Advise patient to hold dose and contact health care professional if pulse is <50 bpm or BP changes significantly. May cause drowsiness or dizziness.

    Does Coreg cause joint pain? ›

    Carvedilol (Coreg) is a type of medication known as a beta blocker, which relaxes the muscle cells in the heart and blood vessels to lower blood pressure. Carvedilol is used to treat high blood pressure and heart failure. almostUp to 6% of people who take it report joint aches and back pain.

    Does Coreg affect vision? ›

    Other side effects include: angina pectoris, hypotension, nausea, orthostatic hypotension, rales, visual disturbance, and vomiting.

    Does Coreg cause hair loss? ›

    I have appealed to my cardiologist to help me with this problem and she has offered to switch me from carvedilol (Coreg) to metoprolol (Toprol). If this doesn't work, what'll I do? A. Beta blockers like atenolol, carvedilol, metoprolol and propranolol can lead to hair loss.

    Is carvedilol hard on the liver? ›

    Conclusion: In very rare cases, carvedilol can cause important liver toxicity as a chronic cholestatic syndrome which can evolve to cirrhosis.

    What should be checked before giving carvedilol? ›

    Assess patient routinely for evidence of fluid overload (peripheral edema, dyspnea, rales/crackles, fatigue, weight gain, jugular venous distention). Patients may experience worsening of symptoms during initiation of therapy for HF.

    How does carvedilol affect the brain? ›

    Carvedilol could act to ensure a continuous flow of blood through the brain, protecting the brain cells. Experiments in mouse models suggest that it interferes with the build-up of amyloid-beta fragments in the brain.

    Does carvedilol cause fatigue? ›

    May cause tiredness, dizziness, diarrhea, nausea, weight gain, and laboratory abnormalities. If the heart rate drops below 55 beats per minute, the dosage of carvedilol should be reduced.

    What is the black box warning for carvedilol? ›

    Acute exacerbation of coronary artery disease upon cessation of therapy; do not abruptly discontinue. Bradycardia, hypotension, worsening heart failure/fluid retention may occur. Reduce dose as needed.

    What happens if you take carvedilol on an empty stomach? ›

    If you take Carvedilol Sandoz on an empty stomach, it may increase the risk of some side effects. Treatment with Carvedilol Sandoz is usually long term treatment. Continue taking Carvedilol Sandoz until your doctor tells you to stop.

    What pain reliever can I take with carvedilol? ›

    No interactions were found between carvedilol and Tylenol. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

    Can you eat bananas while taking carvedilol? ›

    Does carvedilol interact with bananas? No, carvedilol doesn't interact with bananas. Some other medications used for high blood pressure may interact with bananas, which have high levels of potassium.

    Why does carvedilol cause weight gain? ›

    Doctors aren't sure exactly why some beta blockers cause weight gain. It could be that beta blockers slow your metabolism. Also, if you switch from taking a water pill (diuretic) to a beta blocker as a treatment for high blood pressure, you may gain a few pounds of weight that the diuretic kept off.

    Does Coreg cause leg swelling? ›

    Dosage for Coreg

    Coreg may have serious side effects that include hypotension, chest pain, irregular heartbeat, difficult breathing and swallowing, hives or rash, swelling, and fainting.

    What happens if you take too much Coreg? ›

    What happens if I overdose on Carvedilol (Coreg)? Overdose symptoms may include uneven heartbeats, shortness of breath, bluish-colored fingernails, dizziness, weakness, fainting, and seizure (convulsions).

    How many hours is carvedilol effective? ›

    The plasma half-life of carvedilol ranges from 7 to 10 hours in most subjects; thus, the drug requires twice-daily dosing.

    Can carvedilol worsen heart failure? ›

    Adverse events associated with the alpha- and beta-blocking effects of the drug occurred more commonly with carvedilol than with placebo, whereas placebo recipients were more likely to experience worsening heart failure.

    Does carvedilol affect systolic or diastolic? ›

    Carvedilol caused a significant reduction in systolic and diastolic BP (Figure 6A) and LVH, as measured by left ventricular mass in addition to left ventricular mass index (Figure 6B). Effect of carvedilol on left ventricular hypertrophy in hypertensive patients.

    How long should you take carvedilol? ›

    Dosing
    1. For heart failure: Adults—At first, 10 milligrams (mg) once a day for at least two weeks. ...
    2. For hypertension: Adults—At first, 20 milligrams (mg) once a day for 7 to 14 days. ...
    3. For left ventricular dysfunction after a heart attack: Adults—At first, 20 milligrams (mg) once a day for 3 to 10 days.

    What is the safest beta blocker? ›

    Based on research studies, there are three beta blockers that are best for heart failure: carvedilol, metoprolol succinate (the long-acting form of metoprolol), and bisoprolol. These beta blockers have been shown to lower your risk of dying from heart failure complications.

    Does carvedilol cause fluid retention? ›

    However, in some patients the introduction of therapy can be associated with a period of clinical instability, including risks of fluid retention, hypotension, and bradycardia.

    When should you not give Coreg? ›

    Warnings. You should not take Coreg if you have asthma, bronchitis, emphysema, severe liver disease, or a serious heart condition such as heart block, "sick sinus syndrome," or slow heart rate (unless you have a pacemaker).

    Why you should not take gabapentin? ›

    Gabapentin may cause vision changes, clumsiness, unsteadiness, dizziness, drowsiness, sleepiness, or trouble with thinking. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert, well-coordinated, or able to think or see well.

    How much does Coreg lower BP? ›

    Early studies have shown that single administration of carvedilol 25–50 mg results in a consistent reduction in BP over 24 hours compared with placebo, confirming its activity throughout daily activity and sleeping periods. Approximately 90% of the peak reduction in BP is observed at the time of the next dose.

    What are the worst side effects of carvedilol? ›

    Advertisement
    • Allergy.
    • chest pain, discomfort, tightness, or heaviness.
    • dizziness, lightheadedness, or fainting.
    • generalized swelling or swelling of the feet, ankles, or lower legs.
    • pain.
    • slow heartbeat.
    • weight gain.

    How long does it take for Coreg to lower heart rate? ›

    Carvedilol slows down your heart rate and makes it easier for your heart to pump blood around your body. You'll usually take carvedilol once or twice a day. It usually starts to work after about 1 hour.

    Videos

    1. Carvedilol
    (Riverside Rx Services)
    2. Many Heart Failure Patients Cannot Tolerate Recommended Doses of Beta Blockers
    (HCPLive)
    3. 💊What is carvedilol?. Side effects, uses, benefits and doses of carvedilol (Coreg/Coreg CR).💊
    (Medicines/Diseases)
    4. What does Coreg do for you ? | BEST Health FAQS
    (BEST HEALTH Answers)
    5. Carvedilol 3.125 mg, 6.25 mg, 12.5 mg and 25 mg uses dosage and side effects
    (Pharmacist Tips)
    6. Hydralazine Medication Information (dosing, side effects, patient counseling.
    (RxLearn)
    Top Articles
    Latest Posts
    Article information

    Author: Fr. Dewey Fisher

    Last Updated: 11/15/2022

    Views: 6460

    Rating: 4.1 / 5 (62 voted)

    Reviews: 93% of readers found this page helpful

    Author information

    Name: Fr. Dewey Fisher

    Birthday: 1993-03-26

    Address: 917 Hyun Views, Rogahnmouth, KY 91013-8827

    Phone: +5938540192553

    Job: Administration Developer

    Hobby: Embroidery, Horseback riding, Juggling, Urban exploration, Skiing, Cycling, Handball

    Introduction: My name is Fr. Dewey Fisher, I am a powerful, open, faithful, combative, spotless, faithful, fair person who loves writing and wants to share my knowledge and understanding with you.